Reagents for rapid peptide synthesis

A compound of the formula:

• ##STR40## wherein R is an electron withdrawing group;
• R.sub.1 is H;
• X.sub.1 and X.sub.2 are independently hydrogen, lower alkyl, aryl, aryl lower alkyl or polystyrene;
• or
• R and X.sub.1 taken together with the carbon atoms to which they are attached form a monocyclic ring containing a sulfur ring atom or form a bicyclic or tricyclic ring so that said compound has the formula ##STR41## B is a chemical bond, CR.sub.8 R.sub.9 ##STR42## SO.sub.2, SO, or S;
• F is a chemical bond, CR.sub.12 R.sub.13, SO.sub.2, S, SO or ##STR43## Ring G is a mono or bicyclic fused ring system containing 5 to 10 ring carbon atoms and up to 2 ring heteroatoms wherein said ring heteroatoms are S, N or O, with the proviso that when ring G does not contain a ring heteroatom, then at least one of B or F is ##STR44## SO.sub.2, SO, or S;
• and R.sub.8, R.sub.9, R.sub.11, R.sub.12 and R.sub.13 are independently hydrogen or lower alkyl.

A compound of the formula:

• ##STR45## wherein R.sub.1 is H or COZ;
• R is an electron withdrawing group;
• X.sub.1 and X.sub.2 are independently hydrogen, lower alkyl, aryl, aryl lower alkyl or polystyrene;
• or
• R and X.sub.1 taken together with the carbon atoms to which they are attached form a monocyclic ring containing a sulfur ring atom or form a bicyclic or tricyclic ring so that said compound has the formula:
• ##STR46## Z is an amino acid residue or peptide residue;
• B is a chemical bond, CR.sub.8 R.sub.9, ##STR47## SO.sub.2, SO or S;
• F is ##STR48## SO.sub.2, SO, S or CR.sub.12 R.sub.13 ;
• Ring G is a mono or bicyclic fused ring system containing 5 to 10 ring carbon atoms and up to 2 ring heteroatoms wherein the heteroatoms are S, O, or N, with the proviso that when ring G does not contain a ring heteroatom, then at least one of B or F is ##STR49## SO.sub.2, SO or S;
• and R.sub.8, R.sub.9, R.sub.11, R.sub.12 and R.sub.13 are independently hydrogen or lower alkyl.

A compound of the formula:

• ##STR50## wherein R is 2-pyridyl or 4-pyridyl;
• R.sub.1 is H or COZ;
• X.sub.1 and X.sub.2 are independently hydrogen, lower alkyl, aryl, aryl lower alkyl or polystyrene;
• and
• Z is an amino acid residue, a peptide residue or a leaving group.