Certain azacycloalkyl imidazopyrimidines: a new class of GABA brain receptor ligands

A compound of the formula:

• ##STR29## or the pharmaceutically acceptable non-toxic salts thereof wherein W is phenyl, 2- or 3-thienyl or 2-, 3-, or 4-pyridyl;
• or phenyl, 2- or 3-thienyl or 2-, 3-, or 4-pyridyl, each of which is mono or disubstituted with halogen, lower alkyl, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
• and
• Y is
• i) hydrogen, phenyl, 2- or 3-thienyl, 2-, 3- or 4-pyridyl, 2- or 4(5)-imidazolyl, 2-pyrimidinyl, or 1-indanyl;
• ii) phenyl, 2- or 3-thienyl, 2-, 3- or 4-pyridyl, 2- or 4(5)-imidazolyl, or 2-pyrimidinyl, each of which is mono or disubstituted with halogen, lower alkyl having 1-6 carbon atoms, lower alkoxy having 1-6 carbon atoms, or alkoxylalkyl where the alkoxy portion is straight or branched chain alkoxy having 1-6 carbon atoms and the alkyl portion is straight or branched chain alkyl having 1-6 carbon atoms;
• iii) straight or branched chain alkyl having 1-6 carbon atoms;
• iv) straight or branched chain alkyl having 1-6 carbon atoms, wherein each alkyl is substituted with the groups of ii;
• v) cycloalkyl having 3-10 carbon atoms, cycloalkyl alkyl where the cycloalkyl portion has 3-7 carbon atoms and the alkyl portion has 1-6 carbon atoms;
• vi) aminoalkyl where the alkyl portion is straight or branched chain alkyl having 1-6 carbon atoms, or mono or dialkyl aminoalkyl where each alkyl is a straight or branched chain alkyl having 1-6 carbon atoms;
• or
• vii) COR.sub.7 or SO.sub.2 R.sub.7 where R.sub.7 is straight or branched chain lower alkyl having 1-6 carbon atoms, phenyl, 2- or 3-thienyl, 2-, 3- or 4-pyridyl, 2- or 4(5)-imidazolyl, or 2-pyrimidinyl;
• or R.sub.7 is phenyl, 2- or 3-thienyl, 2-, 3- or 4-pyridyl, 2- or 4(5)-imidazolyl, or 2-pyrimidinyl each of which may be mono or disubstituted with halogen, lower alkyl having 1-6 carbon atoms, straight or branched alkoxy having 1-6 carbon atoms, or alkoxyalkyl where the alkoxy portion is straight or branched chain alkoxy having 1-6 carbon atoms and the alkyl portion is straight or branched chain alkyl having 1-6 carbon atoms.