2-arylamidothiazole derivatives with CNS activity

A compound of the formula:

• ##STR4## where R.sub.1, R.sub.2 and R.sub.3 are, independently, H, alkyl of 1 to 6 carbon atoms, halo, perhaloalkyl of 1 to 6 carbon atoms, hydroxy, alkoxy of 1 to 6 carbon atoms, aryl of 6 to 10 carbon atoms or arylalkyl of 7 to 12 carbon atoms;
• n is one of the integers 0, 1, 2, 3, 4 or 5;
• R is azabicyclo 2.2.2!octyl or azabicyclo 2.2.1!heptyl when n.sub.1 is zero, or R is NR.sub.4 R.sub.5 when n.sub.1 is 1, 2, 3, 4, or 5, in which R.sub.4 and R.sub.5 are alkyl of 1 to 6 carbon atoms or R.sub.4 and R.sub.5, taken with the nitrogen atom to which they are attached, are N-(substituted aryl)piperazinyl in which said substituent is alkoxy of 1 to 6 carbon atoms, halo, or perhaloalkyl of 1 to 6 carbon atoms, and the aryl group contains 6 to 10 carbon atoms;
• N-(pyridyl)piperazinyl;
• N-(pyrimidinyl)piperazinyl;
• or 3-azabicyclo- 3.2.2!non-3-yl;
• X is oxygen or NH;
• n and n.sub.1 are, independently, one of the integers 0, 1, 2, 3, 4 or 5;
• or a pharmaceutically acceptable salt thereof.