US 5,510,475 A · Oligonucleotide multiple reporter precursors

Abstract

Oligonucleotides containing multiple free amino groups attached directly to the phosphorus atoms of the phosphodiester linkages having the structure shown below. ##STR1## wherein D=a ribonucleoside or deoxyribonucleotide; p=a 5' to 3'-phosphodiester or phosphoramidate linkage; n=1 to 20; a=1 to 20; b=1 to 20; c=1=20; z=0 to 20; t=1 to 100; and wherein for each repeating unit, "a" represents the same number or a different number than that number represented by "a" in every other repeating unit; and for each repeating unit "b" represents the same number or a different number than represented by "b" in every other repeating unit. Multiple reporter molecules can be incorporated into the oligonucleotide via the free amino groups allowing for increased probe sensitivity.

Claims3

Dependent claims

A compound represented by the formula:

##STR7## wherein D=a ribonucleoside or deoxyribonucleotide;
p=a 5' to 3'-phosphodiester or phosphoramidate
linkage;
n=1 to 20;
a=1 to 20;
b=1 to 20;
c=1 to 20;
z=0 to 20;
t=1 to 100;
and
wherein
for each repeating unit, "a" represents the same number or a different number than that number represented by "a" in every other repeating unit;
and for each repeating unit "b" represents the same number or a different number than represented by "b" in every other repeating unit.

10 more elements

Dependencies are inferred from the claim text.

Oligonucleotide multiple reporter precursors

Life of this patent

Oligonucleotide multiple reporter precursors

Life of this patent

Abstract

Claims3