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US 5,510,469 AGranted
2-acyloxy-4-morpholinyl anthracyclines
AssigneeFarmitalia Carlo Erbq S.r.l.
InventorsDaniela Faiardi, Alberto Bargiotti, Antonino Suarato
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Abstract
Anthracycline glycosides of formula 1: ##STR1## wherein R.sub.1 is hydrogen or methoxy group; R.sub.2 is hydrogen or hydroxy; both R.sub.3 and R.sub.4 represent hydrogen or one of R.sub.3 and R.sub.4 is hydroxy and the other of R.sub.3 and R.sub.4 a represents hydrogen; R.sub.5 represents hydrogen atom or an acyl residue--COX in which X is a C.sub.1 -C.sub.8 linear or branched alkyl chain, an aryl, an aryl lower alkyl, or a 5- or 6-membered heteroaromatic group are anti-tumour agents.
Claims2
An anthracycline glycoside of formula 1:
- ##STR6## wherein R.sub.1 is a methoxy group;
- R.sub.2 is hydroxy;
- R.sub.3 is hydroxy;
- R.sub.4 represents hydrogen;
- R.sub.5 represents an acyl residue --COX in which is X is a phenyl group;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.