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US 5,510,460 AGranted
Peptide process
AssigneeZeneca Limited
InventorChristopher F. Hayward
Life of this patent
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Abstract
A process for the solid phase synthesis of peptides containing an aza-amino acid, for example the decapeptide goserelin, which comprises: (i) assembling all the amino acids of the peptide except the C-terminal aza-amino acid by conventional solid phase synthesis; (ii) cleaving the peptide from the support with hydrazine or a substituted hydrazine; and (iii) reacting the hydrazide thus released with a cyanate ion.
Claims1
A process for solid phase synthesis of goserelin which comprises:
- (i) synthesizing all the amino acids of goserelin except the C-terminal aza-glycine by conventional solid phase synthesis;
- (ii) cleaving the peptide from the support with hydrazine or a substituted hydrazine;
- and
- (iii) reacting the hydrazide thus released with a cyanate ion to form goserelin.
1 more element
Dependencies are inferred from the claim text.