Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
AssigneeAlcon Laboratories, Inc.
InventorsJohn E. Bishop, Louis DeSantis, Jr., Verney L. Sallee
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Abstract
Disclosed is the use of cloprostenol, fluprostenol, and their pharmaceutically acceptable salts and esters for the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic compositions comprising said compounds.
Claims20
A method of treating glaucoma and ocular hypertension which comprises topically administering to the affected eye a therapeutically effective amount of a compound of formula:
- ##STR9## wherein:
- R.sup.1 =hydrogen, a cationic salt moiety, a pharmaceutically acceptable amine moiety or C.sub.1 -C.sub.12 alkyl, cycloalkyl or aryl;
- and R.sup.2 =Cl or CF.sub.3.
A topical ophthalmic composition for the treatment of glaucoma and ocular hypertension in primates, comprising a therapeutically effective amount of a compound of formula:
- ##STR10## wherein:
- R.sup.1 =hydrogen, a cationic salt moiety, a pharmaceutically acceptable amine moiety or C.sub.1 -C.sub.12 alkyl, cycloalky or aryl;
- and R.sup.2 =Cl or CF.sub.3.
A method of treating glaucoma and ocular hypertension, which comprises topically administering to the affected eye a therapeutically effective amount of a compound of formula:
- ##STR11## wherein:
- R.sup.1 =a pharmaceutically acceptable ester moiety;
- and R.sup.2 =Cl or CF.sub.3.
Dependencies are inferred from the claim text.