Nonpeptide bradykinin antagonists
AssigneeSterling Winthrop Inc.
InventorsPeter R. Seoane, Joseph M. Salvino, Brent D. Douty, Mohamed M. A. Awad, Roland E. Dolle, David G. Sawutz, David M. Faunce, Wayne T. Houck
Life of this patent
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Abstract
Disclosed are nonpeptides having bradykinin antagonist activity of the formulae (I) and (II) ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and methods of treating diseased or pathological conditions using the pharmaceutical compositions.
Claims12
A nonpeptide bradykinin receptor antagonist compound of the formulae (I) and (II) ##STR112## or a pharmaceutically acceptable salt thereof wherein
- R.sup.1 and R.sup.2 are independently H, phenyl-substituted or unsubstituted alkyl, cycloalkyl or phenyl in which one or two hydrogen atoms are optionally replaced by lower-alkyl;
- R.sup.3 is phenyl, halophenyl, naphthyl or phenyl--C(.dbd.)-phenylene;
- R.sup.4 is phenyl substituted with -alkyl-P.sup.+ (alkyl).sub.3 ;
- R.sup.5 is H or alkyl;
- R.sup.6 is ##STR113## and R.sup.7 is H or alkyl.
A pharmaceutical composition comprising a nonpeptide bradykinin antagonist of the formulae (I) and (II) ##STR114## or a pharmaceutically acceptable salt thereof wherein R.sup.1 and R.sup.2 are independently H, phenyl-substituted or unsubstituted alkyl, cycloalkyl or phenyl in which one or two hydrogen atoms are optionally replaced by lower-alkyl;
- R.sup.3 is phenyl, halophenyl, naphthyl or phenyl--C(.dbd.O)-phenylene;
- R.sup.4 is phenyl substituted with -alkyl-P.sup.+ (alkyl).sub.3 ;
- R.sup.5 is H or alkyl;
- R.sup.6 is ##STR115## and R.sup.7 is H or alkyl
- in combination with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.