Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents

A compound of the formula:

• ##STR25## wherein:
• R.sub.o is naphthyl, 5,6,7,8-tetrahydronaphth-(1 or 2)-yl, 5,8-dihydronaphth-(1 or 2)-yl;
• or ##STR26## and R.sub.2, R.sub.2 ', R.sub.2 may be the same or different and are hydrogen, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, hydroxy, halogen (chlorine, bromine, fluorine or iodine), trifluoromethyl, carboxy, hydroxy(C.sub.1 -C.sub.10)alkyl, (C.sub.1 -C.sub.10)-alkoxycarbonyl or thio(C.sub.1 -C.sub.4)alkyl;
• n is an integer from 1 to 3;
• X is a divalent radical of ##STR27## wherein R.sub.3 is hydrogen, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)acyl, (C.sub.1 -C.sub.4)alkoxycarbonyl or benzoyl;
• and wherein * denotes an asymmetric carbon;
• R.sub.1 is hydrogen or (C.sub.1 -C.sub.4)alkyl;
• R.sub.4 and R.sub.4 ' may be the same or different and are hydrogen, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, hydroxy, halogen (chloride, bromine, fluorine or iodine), trifluoromethyl, carboxy, hydroxy(C.sub.1 -C.sub.10)alkyl, (C.sub.1 -C.sub.10)alkoxycarbonyl, thio(C.sub.1 -C.sub.4)alkyl;
• R.sub.5 and R.sub.6 hydrogen, carboxyl, (C.sub.1 -C.sub.10)alkoxycarbonyl, hydroxymethyl, --CH.sub.2 OCH.sub.2 COOR.sub.7, --CH.sub.2 OCH.sub.2 CH.sub.2 OR.sub.7, wherein R.sub.7 is hydrogen, or (C.sub.1 -C.sub.4)alkyl, or CONHR.sub.8, R.sub.8 is hydrogen, straight or branched (C.sub.1 -C.sub.10)alkyl or 2-methoxy-1-ethyl;
• with the proviso that R.sub.5 and R.sub.6 may not be hydrogen;
• and the pharmacologically acceptable salt or ester thereof;
• the racemic mixture thereof or the diastereomeric mixture thereof.