Antiparasitic macrolide antiobiotics
AssigneePfizer Inc.
InventorsMark A. Haxell, David A. Perry, Hiroshi Maeda, Junsuke Tone
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Abstract
The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pest, acari, free-living nematodes and endo- and ectoparasites. This invention also relates to pharmaceutical and other compositions comprising such compounds, methods of using such compounds, the microorganism Streptomyces hygroscopicus ATCC 53718 and mutants or genetically transformed or recombinant form thereof, and processes for producing such compounds.
Claims19
A compound of the formula ##STR2## wherein R is H;
- R.sup.1 is H or OCOCH(CH.sub.3).sub.2 ;
- R.sup.2 is OH;
- and
- R.sup.3 is H or OCOCH(CH.sub.3).sub.2 ;
- and with the proviso that R.sup.1 and R.sup.3 may not both be H.
A compound of the formula ##STR3## wherein R is CH.sub.3, R.sup.2 is OH, R.sub.3 is OCOCH(CH.sub.3).sub.2 and R.sup.1 is H, OCOCH(CH.sub.3).sub.2 or OCOCH(CH.sub.3)CH.sub.2 CH.sub.3.
Dependencies are inferred from the claim text.