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US 5,510,368 AGranted
N-benzyl-3-indoleacetic acids as antiinflammatory drugs
AssigneeMerck Frosst Canada, Inc.
InventorsCheuk K. Lau, Cameron Black, Michel Belley
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Abstract
The invention encompasses the novel compound of Formula I as well as a method of treating inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
Claims9
A compound of structural Formula I:
- ##STR7## or a pharmaceutically acceptable salt thereof, wherein:
- R is H, methyl, ethyl or propyl;
- R.sup.1 is halo or methyl;
- R.sup.2 is --H, methyl or ethyl;
- R.sup.3 is Br.
2 more elements
A compound which is
- (S)-(+)-2-(5-Bromo-1-(4-bromobenzyl)-2-methyl-1H-indol-3-yl)propionic acid, sodium salt.
Dependencies are inferred from the claim text.