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US 5,510,365 AGranted
Medicaments containing 1-thiocarbamoyl-5-hydroxy-pyrazoles and their use as agents for combating septic shock
AssigneeBayer Aktiengesellschaft
InventorsPeter Wachtler, Lutz Heuer, Michael Sperzel, Klaus G. Stunkel
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of 1-thiocarbamoyl-5-hydroxypyrazoles of the general formula ##STR1## in which the substituents denote the radicals mentioned in the description, as pharmaceutical agents for combating septic shock and the consequences thereof.
Claims6
Compounds of the formula (I) ##STR345## in which R.sup.1 and R.sup.2 denote hydrogen,
- R.sup.3 denotes substituted alkyl or aralkyl, and
- R.sup.4 denotes hydrogen or unsubstituted or substituted alkyl or aralkyl.
A compound of the formula ##STR346## in which R.sup.1 and R.sup.2 denote H, alkenyl or aryl, with the proviso that
- R.sup.1 and R.sup.2 are not simultaneously hydrogen and R.sup.1 or R.sup.2 are not allyl, and
- R.sup.3 represents substituted alkyl or unsubstituted or substituted alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkyl (cycloalkyl), alkenyl (cycloalkenyl), alkoxy, alkylthio, aralkoxy, aralkylthio, aralkyl, aryl, hetaryl, aryloxy, hetaryloxy, arylthio, hetarylthio, alkoxycarbonyl, alkoxycarbonyl alkyl or cyanoalkyl,
- R.sup.4 represents hydrogen, or unsubstituted or substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkyl (cycloalkyl), alkenyl (cycloalkenyl), alkoxy, alkylthio, aralkoxy, aralkylthio, aralkyl, aryl, hetaryl, aryloxy, hetaryloxy, arylthio, hetarylthio, alkoxycarbonyl, alkoxycarbonyl alkyl or cyanoalkyl, or
- R.sup.3 and R.sup.4 form a saturated or partially or completely unsaturated unsubstituted or substituted ring of 5 to 9 atoms in total, all of which are carbon atoms except for a maximum of two nitrogens, sulphur or oxygen atoms, or their metal complexes.
1 more element
A compound of the formula ##STR347##
Dependencies are inferred from the claim text.