Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents
AssigneeThe Procter & Gamble Company
InventorsMichael W. Scherz, Stanislaw Pikul
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Abstract
The subject invention relates to compounds having the structure: ##STR1## wherein a) each R is independently alkyl having from 1 to about 7 carbon atoms; b) Z is O or N--X; c) X is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, C(O)Y, C(S)Y, and SO.sub.2 Y; d) Y is selected from R', OR' and NR'.sub.2 ; and e) R' is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, and phenyl. The subject invention also relates to pharmaceutical compositions comprising the above compounds, and methods of treating inflammation or pain using the compounds.
Claims14
A compound having the structure:
- ##STR10## wherein a) each R is independently substituted or unsubstituted cycloalkyl or alkyl having from 1 to about 7 carbon atoms;
- b) Z is O or N--X;
- c) X is selected from the group consisting of hydrogen, alkyl having from 1 to about7 carbon atoms, C(O)Y, C(S)Y, and SO2Y;
- d) Y is selected from the group consisting of R', OR'and NR'.sub.2 ;
- and
- e) R' is selected from the group consisting of hydrogen, alkyl having from 1 to about 7 carbon atoms, and phenyl.
Dependencies are inferred from the claim text.