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US 5,510,346 AGranted
4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines
AssigneeHoechst Marion Roussel, Inc.
InventorsLawrence L. Martin, Joseph F. Payack, Salvatore M. Brucato
Life of this patent
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Abstract
Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety utilizing compounds and compositions thereof are disclosed.
Claims51
A compound of the formula
- wherein Ar is a radical selected from the group consisting of ##STR21## wherein R.sup.2 is hydrogen, loweralkyl or loweralkanoyl, Y is selected from the group consisting of halogen, hydroxyl, loweralkyl, loweralkoxy, and trifluoromethyl, n is an integer having a value from 0 to 3 inclusive, p is an integer having a value of 0 or 1, and q is an integer having a value from 0 to 4 inclusive;
- X is selected from the group consisting of halogen, hydroxyl, nitro, loweralkyl, loweralkoxy, and trifluoromethyl;
- m is an integer having a value from 0 to 2 inclusive;
- R is selected from the group consisting of hydrogen, loweralkyl, aryl, aralkyl, cycloalkylloweralkyl, loweralkenyl, and loweralkynyl;
- and R.sup.1 is selected from the group consisting of hydrogen, loweralkyl, and aralkyl, wherein for each value of m, n, p, or q each X or Y may be the same or different;
- the optical antipodes;
- geometrical isomers;
- or pharmaceutically acceptable acid addition salts thereof.
5 more elements
Dependencies are inferred from the claim text.