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AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsZoltan Tuba, Sandor Maho, Aniko Gere, Pal Vittay, Bela Kiss, Eva Palosi, Laszlo Szporny, Csaba Szantay, Ferenc Soti, Zsuzsa Baloghne Kardos, Maria Incze, Gabor Balogh, Maria Gazdag
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The invention relates to novel eburnamenine derivatives of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 as well as R.sup.3 and R.sup.4, independently from each other, stand for hydrogen, C.sub.2-6 alkyl group, C.sub.2-6 alkenyl group; or a C.sub.3-10 alicyclic group involving 1 to 3 rings, and this latter group may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4, together with the adjacent nitrogen atom and optionally with an additional oxygen or nitrogen atom, form a 4- to 6-membered, saturated or unsaturated cyclic group which may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; two of X, Y and Z are nitrogen whereas the third of them means a methine group; n is 1 or 2; W means oxygen or two hydrogen atoms; and the wavy line means .alpha.-/.alpha.-, .alpha.-/.beta.- or .beta.-/.alpha.- steric position, as well as their acid addition salts and solvates. The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for preparing the compounds of formula (I). The compounds of formula (I) possess antioxidant effect and therefore, they are useful for inhibiting the peroxidation of lipids occurring in mammals (including human).
A compound of the formula ##STR19## wherein R.sup.1 and R.sup.2 as well as R.sup.3 and R.sup.4, independently from each other, are hydrogen, C.sub.2-6 alkyl group, C.sub.2-6 alkenyl group;
A compound selected from the group consisting of
Dependencies are inferred from the claim text.