Method of lowering cholesterol
AssigneesAmerican Home Products Corporation, Wake Forest University
InventorsScott A. Washburn, Thomas B. Clarkson, Steven J. Adelman, Michael S. Dey
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Abstract
This invention provides a method of lowering cholesterol and blood lipid levels, preventing hypercholesterolemia, hyperlipidemia, cardiovascular disease, atherosclerosis, and peripheral vascular disease comprising administering an effective amount of 17.alpha.-dihydroequilenin or a mammalian metabolic conjugate thereof to a mammal in need thereof.
Claims8
A method of lowering cholesterol levels in a mammal, consisting essentially of administering to a mammal in need of lowered cholesterol levels, a cholesterol lowering effective amount of 17.alpha.-dihydroequilenin or a mammalian metabolic conjugate thereof as said cholesterol lowering ingredient, by a route of administration selected from the group consisting of oral, parental, transdermal, rectal, intravaginal, intranasal and intrabronchial administration.
A method of preventing hypercholesterolemia in a hypercholesterolemically-susceptible mammal, consisting essentially of administering to a hypercholesterolemically susceptible mammal an antihypercholesterolemic effective amount of 17.alpha.-dihydroequilenin or a mammalian metabolic conjugate thereof as antihypercholesterolemic ingredient, by a route of administration selected from the group consisting of oral, parental, transdermal, rectal, intravaginal, intranasal and intrabronchial administration.
A method of lowering blood lipid levels in a mammal, consisting essentially of administering to a mammal in need of lowered blood lipid levels a lipid lowering effective amount of 17.alpha.-dihydroequilenin or a mammalian metabolic conjugate thereof as said lipid lowering ingredient, by a route of administration selected from the group consisting of oral parental, transdermal, rectal, intravaginal, intranasal and intrabronchial administration and wherein said blood lipid is selected from the group consisting of a triglyceride, cholesterol, LDL, and mixtures thereof.
A method of preventing hyperlipidemia in a susceptible mammal, consisting essentially of administering to a hyperlipidemically-susceptible mammal an antihyperlipidemic effective amount of 17.alpha.-dihydroequilenin or a mammalian metabolic conjugate thereof as said antihyperlipidemic ingredient, by a route of administration selected from the group consisting of oral, parental, transdermal, rectal, intravaginal, intranasal and intrabronchial administration.
Dependencies are inferred from the claim text.