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US 5,510,333 AGranted
Inhibitors of Cathepsin G and elastase for preventing connective tissue degradation
AssigneeMerrell Pharmaceuticals Inc.
InventorsMichael R. Angelastro, Philippe Bey, Niall S. Doherty, Michael J. Janusz, Shujaath Mehdi, Norton P. Peet
Life of this patent
Estimating the term…
Abstract
Novel compounds which are chemically linked inhibitors of the proteases Elastase and Cathepsin G prevent connective tissue degradation associated with neutrophil induced inflammatory disease.
Claims10
A compound of the formula ##STR10## wherein P.sub.1 is Val or Nva;
- P.sub.1 ' is Phe;
- P.sub.2 is Pro;
- P.sub.2 ' is Pro or is absent;
- P.sub.3 is Lys, Ala, Ile or Val;
- P.sub.3 ' is Ala, Val or is absent;
- P.sub.4 is Ala or is absent;
- P.sub.4 ' is Ala or is absent;
- L is a --C(O)-phenylene-C(O)-- group;
- EIM and CGIM are each independently selected from the group consisting of --CF.sub.2 CF.sub.3, --CF.sub.3, --CF.sub.2 H, --CO.sub.2 R.sub.3, --CONHR.sub.3, --H, or --C(O)R,
- wherein
- R.sub.3 is H, alkyl, phenyl, benzyl,
- R is OH or alkoxy
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.