Highly concentrated TCF pharmaceutical preparations
AssigneeSnow Brand Milk Products Co., Ltd.
InventorsHitoshi Hayasaka, Nobuyuki Kawashima, Masatsugu Ueda, Eitaro Kumazawa
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Abstract
This invention provides pharmaceutical preparations containing highly concentrated tumor cytotoxic factor (TCF). The pharmaceutical preparations of the present invention contain highly concentrated TCF and a basic amino acid or their salts, or an organic or inorganic salt as a solubizer. The resultant compositions described in the present invention dissolve TCF at high concentrations of 10 mg/ml or over under about neutral and isotonic conditions. The resultant compositions are stable and are suitable for injection preparations.
Claims17
A tumor cytotoxic factor (TCF) composition comprising:
- TCF;
- a basic amino acid or a salt of a basic amino acid;
- and
- a pharmacologically acceptable organic or inorganic salt;
- wherein the amount of TCF is sufficient such that when the composition is dissolved or dispersed in a liquid carrier, the concentration of TCF is at least about 5 mg/ml.
An isotonic injectable TCF preparation having an approximately neutral pH comprising a physiologically acceptable carrier liquid containing:
- at least 5 mg/ml of TCF;
- a basic amino acid or salt of a basic amino acid;
- and
- a pharmacologically acceptable organic or inorganic salt.
A method for improving solubility of TCF in an aqueous liquid, the method comprising combining TCF with a basic amino acid or salt thereof thereby forming a homogeneous mixture;
- and dissolving or dispersing said mixture in the aqueous liquid.
Dependencies are inferred from the claim text.