Antibodies which bind meningitis related homologous antigenic sequences
AssigneeInsight Biotech Inc.
InventorsDiane Van Alstyne, Lawrence R. Sharma
Life of this patent
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Abstract
Monoclonal antibodies capable of binding to a Meningitis Related Homologous Antigenic Sequence (MRHAS) are provided. The MRHAS is found in meningitis-causing organisms and chemokines involved in cell chemotaxis. The monoclonal antibodies are useful for detection and diagnosis of meningitis.
Claims24
A composition comprising a carrier and a monoclonal antibody or antigen-binding fragment thereof which binds to a Meningitis Related Homologous Antigenic Sequence contained in the amino acid sequence of a protein or peptide, wherein said protein or peptide is found in a bacterium or virus that is an etiologic agent of meningitis.
A competition comprising a carrier and a monoclonal antibody or antigen-binding fragment thereof which binds to a Meningitis Related Homologous Antigenic Sequence contained in the amino acid sequence of a protein or peptide, wherein said protein or peptide is a chemokine involved in cell chemotaxis.
A hybridoma cell line that produces a monoclonal antibody or antigenic-binding fragment thereof which binds to a Meningitis Related Homologous Antigenic Sequence contained in the amino acid sequence of a protein or peptide, wherein said protein or peptide is found in a bacterium or virus that is an etiologic agent of meningitis.
A hybridoma cell line designated RV-1 having ATCC deposit accession number HB 11362.
A monoclonal antibody or antigen-binding fragment thereof that binds to an antigenic determinant of a Meningitis Related Homologous Antigenic Sequence contained in the amino acid sequence of protein or peptide found in a bacterium or virus that is an etiologic agent of meningitis, wherein said antigenic determinant is contained within an amino acid sequence selected from the group consisting of SEQ ID NO:1;
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A monoclonal antibody or antigen-binding fragment thereof that binds to an antigenic determinant of a Meningitis Related Homologous Antigenic Sequence contained in the amino acid sequence of protein or peptide that is a chemokine involved in cell chemotaxis, wherein said antigenic determinant is contained within an amino acid sequence selected from the group consisting of SEQ ID NO:36;
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A hybridoma cell line that produces a monoclonal antibody or antigenic-binding fragment thereof which binds to a Meningitis Related Homologous Antigenic Sequence contained in the amino acid sequence of a protein or peptide, wherein said protein or peptide is a chemokine involved in cell chemotaxis.
Dependencies are inferred from the claim text.