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US 5,510,117 AGranted
Entrapment vehicle and method
AssigneeMicro-Pak, Inc.
InventorKenneth Abate
Life of this patent
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Abstract
This invention concerns delivery vehicles entrapping active materials suspended in a water immiscible carrier. Methods of making these materials, preferably using a carboxymethylcellulose support martrix, are disclosed. The vehicles of the invention are especially well adapted to delivery of incompatible actives that can be entrapped separately and kept separately until release from the vehicle.
Claims14
A method of preparing a delivery vehicle having an active material entrapped therein, said delivery vehicle being suspended in a water immiscible carrier, said method consisting essentially of the steps of:
- suspending a particulate support material in an aqueous solution containing the active material to be entrapped, said support material being selected from the group consisting of crosslinkable carboxylated celluloses, chitosan, guar gum, polymethacrylates, polyacrylates, and mixtures thereof;
- blending said support material suspension with a water-immiscible carrier to form a suspension of said support material in said water-immiscible carrier, said active material being insoluble in said water-immiscible carrier;
- adding a cross linking agent to said water-mmiscible carrier, said cross-linking agent being insoluble in said aqueous solution but soluble in said water-immiscible carrier;
- and
- allowing said cross-linking agent to cross-link said support material, said cross-linking occurring at the phase boundary, thereby forming said delivery vehicle;
- whereby said delivery vehicle is in the form of a cross-linked support material having said aqueous solution containing the active material entrapped therein, said delivery vehicle being suspended in said water-immiscible carrier.
3 more elements
Dependencies are inferred from the claim text.