Method and composition for administration of beneficial agent by controlled dissolution
AssigneeBaxter Travenol Laboratories, Inc.
InventorsJulian P. Breillatt, Jr., Lecon Woo, Deanna J. Nelson, Richard Appl, Naomi L. Weinless, Sharon Pokropinski, Paul Soltys, Sumner A. Barenberg
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Abstract
An anhydrous solid water-soluble composition and method for direct controlled administration of beneficial agents to a flowing medical fluid. The beneficial agents are geometrically dispersed in a solid matrix and isolated from one and other to allow administration of mutually reactive agents.
Claims16
A method for delivering a controlled amount of at least one beneficial agent to a flowing medical fluid, said method comprising:
- providing a formed element including a shaped solid matrix having at least one beneficial agent dispersed therein, the matrix comprising a water soluble, anhydrous sugar material, the formed element having a configuration selected so that upon introducing the formed element into a flowing stream of a medical fluid, the formed element dissolves at a dissolution rate selected to release the at least one beneficial agent into the medical fluid at a desired delivery rate;
- providing a flow cell including a chamber connectible to a medical fluid administration line through which a medical fluid flows;
- positioning the formed element in the chamber;
- and
- connecting the flow cell in the medical fluid administration line so that as a flowing stream of a medical fluid passes through the flow cell, the at least one beneficial agent is released into the medical fluid at the desired delivery rate.
An apparatus for delivering a controlled amount of at least one beneficial agent to a medical fluid provided in a medical fluid administration line, the apparatus comprising:
- a flow cell including a chamber adapted to positionably receive a formed element therein;
- a formed element positioned in said chamber, said formed element including a shaped solid matrix having at least one beneficial agent dispersed therein, said matrix comprising a water soluble, anhydrous sugar, the formed element having a configuration selected so that upon introducing a flowing stream of medical fluid through the chamber, the formed element dissolves at a dissolution rate selected to release the at least one beneficial agent into the medical fluid at a desired delivery rate;
- and
- means for connecting the flow cell in line in the medical fluid administration line to permit medical fluid to flow to said flow cell, through the chamber and out of the cell, whereby, the at least one beneficial agent is released by said apparatus into said medical fluid at said desired delivery rate.
Dependencies are inferred from the claim text.