Slow release pharmaceutical composition containing a bile acid as an active ingredient
AssigneeInstituto Biochimico Italiano Giovanni Lorenzini S.p.A.
InventorsFabio Borella, Alberto Brandt, Fabio Carli
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Abstract
A slow-release pharmaceutical composition containing a bile acid as active ingredient and comprising at least one bioadhesive substance and at least one high specific gravity substance, an aliquot thereof being enteric coated and the remainder being non-enteric coated.
Claims8
Slow release pharmaceutical composition containing a bile acid as active ingredient and provided in the form of 0.5-2 mm diameter coated particles suitable to be manufactured in the form of capsules or tablets, wherein the core of said particles consists of 10 to 90% by weight of a bile acid, 1 to 15% by weight of a bioadhesive substance, 5 to 40% by weight of a high specific gravity substance selected from the group consisting of barium sulfate, powdered metallic iron, samarium oxide, erbium oxide, magnesium trisilicate, aluminum trisilicate and titanium dioxide, the balance to 100 being constituted by cellulose or polyvinylpyrrolidone, an aliquot of 40 to 60% by weight of said particles being enteric coated with gastroresistant substances and the remainder being coated with a non-enteric coating.
Dependencies are inferred from the claim text.