Treatment of autoimmune diseases with IL-2 receptor-specific cytotoxins
OwnerTerry B. Strominventor
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Abstract
A method of treating a mammal suffering from an autoimmune disease state is provided. The method comprises administering to the mammal a cytotoxin-conjugated IL-2 receptor-specific substance during a proliferative burst of IL-2 receptor-bearing lymphocytes associated with the disease state, whereby the lymphocytes undergoing the proliferative burst are selectively killed.
Claims11
A method of treating a mammal suffering from an autoimmune disease state-producing immune response characterized by a proliferative burst of IL-2 receptor-bearing lymphocytes, said method comprising administering to said mammal during said proliferative burst, a cytotoxin linked to an IL-2 receptor-specific substance whereby said IL-2 receptor-bearing lymphocytes are killed to the exclusion of non-IL-2 receptor-bearing cells.
Dependencies are inferred from the claim text.