Plasma and polymer containing surgical hemostatic adhesives
AssigneeThe Regents of the University of California
InventorKent C. Cochrum
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Abstract
Autologous platelet-rich plasma and a biocompatible polymer containing hemostatic adhesive agents. The agents have strong hemostatic properties when applied to a bleeding wound or vessel.
Claims17
A hemostatic adhesive agent for triggering clotting process comprising of a platelet-rich plasma concentrate and a physiologically acceptable biocompatible polymer selected from the group-consisting of alginates, poly-L-amino acids, chitosan and chitin
- wherein the platelet-rich plasma concentrate is 5 to 10 times concentrated normal plasma, said concentrate containing 5 to 10 times higher concentration of fibrinogen and other plasma proteins than the normal plasma;
- wherein a platelets to plasma concentrate ratio is from 1:2 to 2:1;
- and
- wherein a platelet-rich plasma concentrate to polymer ratio is from 99:1 to 80:20;
- wt/wt.
A method for attaining hemostasis by triggering clotting process, said method comprising administering, in the presence of a divalent ion, to a site of injury a platelet-rich plasma and a physiologically acceptable biocompatible polymer selected from the group consisting of alginates, poly-L-amino acids, chitosan and chitin,
- wherein the platelet-rich plasma concentrate is 5 to 10 times concentrated normal plasma, said concentrate containing 5 to 10 times higher concentration of fibrinogen and other plasma proteins than the normal plasma;
- wherein a platelets to plasma concentrate ratio is from 1:2 to 2:1;
- and
- wherein a platelet-rich plasma concentrate to polymer ratio is from 99:1 to 80:20 wt/wt.
Dependencies are inferred from the claim text.