Fixed tissue medical devices comprising albumin-binding dyes
OwnerJames R. Keogh, David A. Pearson +1inventors
InventorsJames R. Keogh, David A. Pearson, John W. Eaton
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Abstract
An implantable medical device is provided which comprises a fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. These albumin-binding dyes have been found to significantly reduce calcification when incorporated in tissue heart valves. A method of increasing the albumin-binding ability of an implantable medical device is also provided.
Claims32
An implantable medical device comprising fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when said device is in contact with a physiological fluid containing albumin.
An implantable medical device comprising:
- a surface of fixed tissue and on the fixed tissue surface an amount of a conjugate comprising:
- a. an albumin-binding dye and
- b. a physiologically-acceptable water-soluble polymer, wherein said amount of the conjugate is effective to bind albumin to the fixed tissue surface of said medical device.
A method of increasing the albumin-binding ability of a implantable medical device comprising fixed tissue, said method comprising the step of:
- a. incorporating into said fixed tissue an amount of an albumin-binding dye;
- wherein the amount of the albumin-binding dye is effective to form a coating of endogenous albumin on a surface of said fixed tissue when the surface is in contact with a physiological fluid containing albumin.
Dependencies are inferred from the claim text.