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US 5,508,440 AGranted
Hydroxymethylpolythiophene derivatives
AssigneeIndustrial Technology Research Institute
InventorsChing-Te Chang, Chen-Tao Lee, Fueng-Lan Lin
Life of this patent
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Abstract
Novel hydroxymethylthiophene derivatives and their medical use in treating or preventing inflammation and edema.
Claims6
A compound of the formula:
- ##STR18## in which n is 0;
- R is --CH(R.sup.1)OCH.sub.3, --CH(R.sup.1).OR.sup.2, CH(R.sup.1).O(C.sub.2 -C.sub.6 alkyl), --CH(O--Z).sub.2, or --COR.sup.3 ;
- R.sup.1 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-6 alkoxy, or C.sub.1-6 acyloxy;
- each R.sup.2 and R.sup.4, independently, is H, C.sub.2-6 alkenyl, C.sub.1-6 hydroxyalkyl, C.sub.2-6 alkoxyalkyl, tetrahydropyranyl, or --CO--Y--COOH;
- and
- R.sup.3 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or C.sub.1-6 alkoxy;
- wherein Z is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or C.sub.1-6 acyl;
- and Y is C.sub.1-6 alkylidene, C.sub.2-6 alkenylidene, or phenylene provided that R and --CH(R.sup.1).OR.sup.4 cannot both be CH2OH and further provided that when R is CHO, --CH(R.sup.1).OR.sup.4 cannot be CH2OH;
- or a salt or an ester thereof.
6 more elements
Dependencies are inferred from the claim text.