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US 5,508,437 AGranted
Analogs of tyrosine sulfate or tyrosine phosphate containing peptides
AssigneeHoffmann-La Roche Inc.
InventorsWaleed Danho, Jefferson W. Tilley, Joseph Triscari, Rolf Wagner
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Abstract
Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more of any Tyrosine Sulfate present is substituted with a radical of the invention.
Claims20
A compound of the formula ##STR41## wherein R.sub.1 ' is substituted or unsubstituted lower alkyl with the substituents selected from the group consisting of hydroxy, halogen, or aryl;
- and
- Z'is H, lower alkyl, ##STR42## wherein R.sub.3 and R.sub.4 are H, substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups.
A compound of the formula:
- ##STR43## wherein one of A' or B' is a group of the formula:
- ##STR44## and the other of A' or B' is H wherein R.sub.0 is H or F, R.sub.1 is H, substituted or unsubstituted lower alkyl with the substitutents selected from the group consisting of hydroxy, halogen and aryl, and s is an integer from 1-2;
- R' is H, substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups;
- Z' is H, lower alkyl, --NH.sub.2, ##STR45## wherein R.sub.3 and R.sub.4 are H, substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups.
1 more element
Dependencies are inferred from the claim text.