Spiro compound
AssigneeDaiichi Phamaceutical Co., Ltd.
InventorsIsao Hayakawa, Shohgo Atarashi, Masazumi Imamura, Youichi Kimura
Life of this patent
Estimating the term…
Abstract
A compound of formula I, having antibacterial activity and a pharmaceutical composition containing the compound of formula I: ##STR1## wherein Q represents a partial structure of formula II: ##STR2## wherein all substituents are defined in the specification.
Claims41
A spiro compound of formula I:
- ##STR11## wherein a represents 1;
- b represents an integer equal to 2 through 5, inclusive;
- c represents an integer equal to 0 or 1;
- and d represents an integer equal to 0 through 2, inclusive;
- Z represents >CHR.sup.1, >NR.sup.2 or >C.dbd.NOR.sup.3 wherein R.sup.1 represents a hydrogen atom, an amino group, a monoalkylamino group of 1 to 6 carbon atoms, a dialkylamino group containing 1 to 6 carbon atoms per alkyl group, a hydroxyl group, an alkoxy group of 1 to 6 carbon atoms or a hydroxylalkyl group of 1 to 6 carbon atoms;
- R.sup.2 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms, a formyl group or an alkylcarbonyl group of 2 to 7 carbon atoms;
- and R.sup.3 represents a hydrogen atom or an alkyl group of 1 to 6 carbon atoms;
- or a salt thereof.
7-Amino-5-azaspiro[2.4]heptane or a salt thereof.
8-Amino-6-azaspiro[3.4]octane or a salt thereof.
4-Amino-2-azaspiro[4.4]nonane or a salt thereof.
4-Amino-2-azaspiro[4.5]decane or a salt thereof.
4,7-Diazaspiro[2.5]octane or a salt thereof.
A spiro compound of formula I:
- ##STR12## wherein a represents an integer equal to 1;
- b represents an integer equal to 2 through 5, inclusive;
- c represents an integer equal to 0;
- and d represents an integer equal to 1;
- Z represents >CHR.sup.1, wherein R.sup.1 represents a protected amino group, or a protected hydroxyl group, wherein said protected group is a member selected from the group consisting of an alkoxycarbonyl group, an aralkyloxycarbonyl group, an acyl group, an alkyl group, an aralkyl group, an ether group and a silyl group.
A spiro compound of formula I:
- ##STR13## wherein a represents an integer equal to 1;
- b represents an integer equal to 2 through 5, inclusive;
- c represents an integer equal to 0;
- and d represents an integer equal to 1;
- Z represents >CHR.sup.1, wherein R.sup.1 represents a protected amino group, wherein said protected group is a member selected from the group consisting of an alkoxycarbonyl group, an aralkyloxycarbonayl group, an acyl group, an alkyl group, an aralkyl group, an ether group and a silyl group.
7-Alkoxycarbonylamino-5-azaspiro[2.4]-heptane or a salt thereof.
8-Alkoxycarbonylamino-6-azaspiro[3.4]-octane or a salt thereof.
7-Aralkyloxycarbonylamino-5-azaspiro-[2.4]heptane or a salt thereof.
8-Aralkyloxycarbonylamino-6-azaspiro[3.41octane or a salt thereof.
7-tert-Butoxycarbonylamino-5-azaspiro-[2.4]heptane or a salt thereof.
8-tert-Butoxycarbonylamino-6-azaspiro[3.4]octane or a salt thereof.
Dependencies are inferred from the claim text.