Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation
AssigneeG. D. Searle & Co.
InventorsJohn J. Talley, Thomas D. Penning, Paul W. Collins, Donald J. Rogier, Jr., James W. Malecha, Julie M. Miyashiro, Stephen R. Bertenshaw, Ish K. Khanna, Matthew J. Graneto, Roland S. Rogers, Jeffery S. Carter
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Abstract
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
Claims6
A compound of Formula I ##STR44## wherein R.sup.1 is selected from sulfamyl, halo, alkyl, alkoxy, hydroxyl and haloalkyl;
- wherein R.sup.2 is selected from hydrido, halo, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, amidino, cyanoamidino, amido, alkoxy, amidoalkyl, N-monoalkylamido, N-monoarylamido, N,N-dialkylamido, N-alkyl-N-arylamido, alkylcarbonyl, alkylcarbonylalkyl, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, N-alkylsulfamyl, N-arylsulfamyl, arylsulfonyl, N,N-dialkylsulfamyl, N-alkyl-N-arylsulfamyl and heterocyclic;
- wherein R.sup.3 and R.sup.4 together form ##STR45## wherein m is 1 to 3, inclusive;
- and wherein R.sup.5 is one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, carboxyl, alkoxycarbonyl, amido, N-monoalkylamido, N-monoarylamido, alkyl, N,N-dialkylamido, N-alkyl-N-arylamido, haloalkyl, hydrido, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, sulfamyl, N-alkylsulfamyl, amino, alkylamino, heterocyclic, nitro and acylamino;
- provided at least one of R.sup.1 or R.sup.5 is sulfamyl;
- or a pharmaceutically-acceptable salt thereof.
A compound of Formula II ##STR47## wherein R.sup.2 is selected from hydrido, haloalkyl, alkoxycarbonyl, cyano, amido, arylamido, carboxyalkyl and hydroxyalkyl;
- and
- wherein R.sup.3 and R.sup.4 together form ##STR48## or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.