Retroviral protease inhibitors

A compound having the Formula:

• ##STR12## where:
• R is quinolyl, tetrahydroquinolyl, or quinolyl substituted by oxo, chloro, methoxy, 2-methylpropyl, isopropyl, or one or two fluoro, or methyl groups;
• X is a bond, (--CH.sub.2).sub.q --, --O--(--CH.sub.2 --).sub.q --, --(--CH.sub.2 --).sub.q --O-- or --N(R.sup.5) (CH.sub.2 --).sub.m --;
• q is 1, 2, 3 or 4;
• n is 0, 1, or2;
• R.sup.1 is aryl or C.sub.5 -C.sub.7 cycloalkyl;
• R.sup.2 is an amino acid side chain,
• C.sub.1 -C.sub.4 alkylaminocarbonyl(C.sub.1 -C.sub.4 alkanediyl), or a group having the structure --CH.sub.2 --C(O)--NR.sup.4 --X--R' or --CH.sub.2 --R" where
• R' is pyridyl, imidazolyl, phenyl, benzimidazolyl or indolyl;
• and
• R" is imidazolyl;
• Y is aryl or furyl, thienyl, or benzofuryl;
• R.sup.3 is a group having the structure:
• ##STR13## where:
• l is 3, 4 or 5;
• m at each occurrence is independently 0, 1, 2, or 3;
• p is 4 or 5;
• R.sup.4 at each occurrence is independently hydrogen, C.sub.1 -C.sub.6 alkyl, or hydroxy(C.sub.1 -C.sub.4)alkanediyl;
• R.sup.5 and R.sup.6 are independently selected from hydrogen, hydroxy, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, amino, C.sub.1 -C.sub.4 alkylamino, hydroxy(C.sub.1 -C.sub.4)-alkanediyl, carboxy, C.sub.1 -C.sub.4 alkoxy)carbonyl, aminocarbonyl, C.sub.1 -C.sub.4 alkylaminocarbonyl, or aryl;
• or a pharmaceutically acceptable salt or solrate thereof.