Quinolyl-dihydropyridine esters, processes for their preparation, and their use in medicaments

A 4-quinolyl-dihydropyridine ester of the formula ##STR55## wherein R.sup.1 and R.sup.5 are identical or different and represent methyl or ethyl,

• R.sup.2 represents nitro or cyano
• or
• R.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR56## R.sup.6 represents hydrogen, R.sup.3 represents phenyl which is optionally substituted by fluorine, chlorine, nitro, cyano, hydroxyl, trifluoromethyl, methyl, ethyl, methoxy or ethoxy,
• R.sup.4 represents cyano, nitro or formyl,
• or R.sup.4 and R.sup.5 together form a lactone ring of the formula ##STR57## or R.sup.4 represents a group of the formula --CO--A--R.sup.8 or --CO--NR.sup.9 R.sup.10
• in which
• A denotes a direct bond or an oxygen atom,
• R.sup.8 denotes cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl which are optionally interrupted by the group --NR.sup.11, or denotes a straight-chain, branched, cyclic, saturated or unsaturated substituted hydrocarbon radical having up to 8 carbon atoms which is optionally interrupted by an oxygen atom, phenylidene or by a group of the formula --S(O).sub.a or --NR.sup.11 and is optionally substituted by phenyl,
• in which
• a denotes the number 0 or 2
• and
• R.sup.11 denotes hydrogen or phenyl which is optionally substituted by fluorine, chlorine, methyl or methoxy, or denotes cyclopropyl, cyclopentyl, cyclohexyl, or straight-chain or branched alkyl having up to 4 carbon atoms which is optionally substituted by phenyl,
• and where the hydrocarbon radical, in the case
• where A represents oxygen, is always substituted by cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl or by a group --CO--NR.sup.12 R.sup.13, --NR.sup.14 --CO--R.sup.15, --NR.sup.16 --SO.sub.2 --R.sup.17, --SO.sub.2 --NR.sup.18 R.sup.19, O--NO.sub.2, --O--(CH.sub.2).sub.b --R.sup.20, --S(O).sub.c --(CH.sub.2).sub.4 --R.sup.21, --NR.sup.22 R.sup.23 or --NR.sup.24 --COOR.sup.25,
• in which
• R.sup.12, R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.24 and R.sup.25 are identical or different and have the meaning of R.sup.11 given above, and are identical or different to the latter,
• b denotes the number 1, 2, 3 or 4,
• d denotes the number 0, 1, 2, 3 or 4,
• c has the meaning of a given above, and is identical or different to the latter,
• R.sup.20 and R.sup.21 are identical or different and denote phenyl which is optionally substituted by fluorine, chlorine, methyl or methoxy,
• R.sup.22 and R.sup.23 are identical or different and denote hydrogen or a straight-chain, branched, saturated, unsaturated or cyclic hydrocarbon radical having up to 4 carbon atoms which is optionally substituted by fluorine, chlorine, cyclopropyl, cyclopentyl, cyclohexyl, phenyl or phenoxy, which are optionally substitute by fluorine, chlorine, methyl or methoxy,
• or
• R.sup.22 and R.sup.23, together with the nitrogen atom, form a piperidine or piperazine ring, which is optionally substituted by benzyl,
• or the hydrocarbon radical, in the case where A represents oxygen, is substituted by pyridyl, tetrahydropyranyl, pyrazolyl, furyl, or chromanyl, or by a radical of the formula ##STR58## R.sup.9 and R.sup.10 are identical or different and denote hydrogen, a straight-chain, branched, cyclic, saturated or unsaturated hydrocarbon radical having up to 6 carbon atoms which may optionally be substituted by phenol, or denote phenyl or pyridyl,
• or a pharmaceutically acceptable salt thereof.