Substituted dibenzo[a,d]cycloheptene NMDA antagonists
AssigneeAmerican Home Products Corporation
InventorsWayne E. Childers, Jr., Magid A. Abou-Gharbia, Edward J. Podlesny
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Abstract
This invention involves novel neuroprotectant agents of the formula: ##STR1## in which R.sup.1 and R.sup.3 are, independently, hydrogen, cyano, nitro, halo or perhaloalkyl, with the proviso that one of R.sup.1 and R.sup.3 is other than hydrogen; R.sub.2 is alkyl; or a pharmaceutically acceptable salt thereof.
Claims6
A compound which is 10,11-dihydro-3-bromo-5-methyl-10,5-(iminomethano)-5H-dibenzo[a,d]cyclohep tene, or a pharmaceutically acceptable salt thereof.
A compound which is 10,11-dihydro-7-bromo-5-methyl-10,5-(iminomethano)-5H-dibenzo[a,d]cyclohep tene, or a pharmaceutically acceptable salt thereof.
A compound which is 10,11-dihydro-3-chloro-5-methyl-10,5-(iminomethano)-5H-dibenzo[a,d]cyclohe ptene, or a pharmaceutically acceptable salt thereof.
A compound which is 10,11-dihydro-3-fluoro-5-methyl-10,5-(iminomethano)-5H-dibenzo[a,d]cyclohe ptene, or a pharmaceutically acceptable salt thereof.
A compound which is (-)-10,11-dihydro-3-bromo-5-methyl-10,5-(iminomethano)-5H-dibenzo[a,d]cycl oheptene, or a pharmaceutically acceptable salt thereof.
A compound which is (+)-10,11-dihydro-3-bromo-5-methyl-10,5-(iminomethano)-5H-dibenzo[a,d]cycl oheptene, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.