Diterpenes having immunomodulatory action
AssigneeMerck Patent GmbH
InventorsHans-Eckart Radunz, Michael Wolf, Manfred Baumgarth, Willy Kinzy, Gerd-Albrecht Luckenbach
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Abstract
Diterpenes of the formula I ##STR1## in which R.sup.1 is --CH.sub.2 --C(CH.sub.3).dbd.CH--R.sup.3 or --CH.sub.2 --CH(CH.sub.3)--CH.sub.2 --R.sup.3, R.sup.3 is --CH.sub.2 OH, --CHO, --COOH or --COOR.sup.4, R.sup.4 is alkyl having 1 to 5 C atoms, A is ##STR2## and R.sup.2 is H, pentoses, hexoses, di-/oligosaccharides or amino sugars, are suitable for production of medicaments having immunomodulatory action, in particular stimulating T-cells.
Claims6
A pharmaceutical preparation comprising an effective amount of a compound of formula I ##STR15## wherein R.sup.1 is --CH.sub.2 --C(CH.sub.3).dbd.CH--R.sup.3 or --CH.sub.2 --CH(CH.sub.3)--CH.sub.2 --R.sup.3,
- R.sup.3 is --CH.sub.2 OH or --CHO,
- A is ##STR16## and R.sup.2 is H, a pentose, a hexose or a disaccharide or a physiologically acceptable acid addition salt thereof,
- and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.