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US 5,508,310 AGranted
Immunopotentiatory agents and physiologically acceptable salts thereof
AssigneeBurroughs Wellcome Co.
InventorJohn R. Rhodes
Life of this patent
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Abstract
This invention relates to the use of a class of compounds as immunopotentiaters, compositions containing such compounds and their manufacture, combinations of such compounds with anti-tumor or anti-infective drugs and the use of such combinations in the prophylaxis or treatment of such diseases arising from tumors or infections.
Claims6
A method for treating an immunodeficient mammal which comprises administering to the mammal an effective amount of a compound of formula (I)
- B.sup.1 --N (I)
- which forms a Schiff base with T-cell surface carbonyl groups, for the potentiation of an immune response, wherein
- N is hydrogen or ##STR33## n is 0 or 1;
- B is hydrogen or C.sub.1-4 alkyl;
- B.sup.1 is optionally substituted phenyl;
- B.sup.2 is methyl or may be linked to B.sup.1 when B.sup.1 is phenyl to form a optionally substituted bicyclic ring system containing 8 or 10 atoms of which one may be oxygen and the rest carbon,
- or when n is 1, B.sup.1 is hydrogen and B.sub.2 is CH.sub.2 CO(CH.sub.2).sub.x COOH wherein x is 1 to 7, with the proviso that the compounds coumarin, cinnaldehyde and 4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid excluded.
4 more elements
Dependencies are inferred from the claim text.