LTB4 synthesis inhibitors
AssigneeG. D. Searle & Co.
InventorsStevan W. Djuric, Richard A. Haack, Julie M. Miyashiro
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Abstract
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CH.dbd.CH--, or --CH.dbd.N--; wherein R.sup.1 is --CO.sub.2 R.sup.2 or tetrazole; wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation; wherein R is an alkyl of from 1 to 20 carbons, --(CH.sub.2).sub.p CF.sub.3 or --(CH.sub.2).sub.q R.sup.3 wherein R.sup.3 is alkoxy, phenoxy or alkoxy substituted phenoxy wherein the alkoxy group has from 1 to 8 carbons; wherein p and q are integers from 0 to 20; wherein n is 0 or 1; and wherein m is 0, 1, 2, or 3.
Claims12
A pharmaceutical composition comprising a compound of the formula ##STR45## or a pharmaceutically acceptable salt thereof wherein X is --CH.dbd.CH--;
- wherein R.sup.1 is --CO.sub.2 R.sup.2 ;
- wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation;
- wherein R is an alkyl of from 1 to 20 carbons, --(CH.sub.2).sub.p CF.sub.3 or --(CH.sub.2).sub.q R.sup.3 wherein R.sup.3 is alkoxy, phenoxy or alkoxy substituted phenoxy wherein the alkoxy group has from 1 to 8 carbons;
- wherein p and q are integers from 0 to 20;
- wherein n is 1;
- and
- wherein m is 0, 1, 2, or 3;
- and a pharmaceutically acceptable carrier.
A method for the treatment of mammals exhibiting an LTB.sub.4 mediated inflammatory condition, comprising administering a compound of the formula ##STR46## or a pharmaceutically acceptable salt thereof wherein X is --CH.dbd.CH--;
- wherein R.sup.1 is --CO.sub.2 R.sup.2 ;
- wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation;
- wherein R is an alkyl of from 1 to 20 carbons, --(CH.sub.2).sub.p CF.sub.3 or --(CH.sub.2).sub.q R.sup.3 wherein R.sup.3 is alkoxy, phenoxy or alkoxy substituted phenoxy wherein the alkoxy group has from 1 to 8 carbons;
- wherein p and q are integers from 0 to 20;
- wherein n is 1;
- and
- wherein m is 0, 1, 2, or 3.
Dependencies are inferred from the claim text.