Aromatic amine derivatives

A compound having the structure:

• ##STR140## wherein each W and Z.sup.1 is independently H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, OH, NO.sub.2, CN, SO.sub.2 NHR.sup.3, NR.sup.4.sub.2, CONR.sup.3.sub.2, COR.sup.5 ;
• Z.sup.2 is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, OH, NO.sub.2, CN, SO.sub.2 NHR.sup.3, NR.sup.4.sub.2, CONR.sup.3.sub.2, COR.sup.5 ;
• wherein each R.sup.1 and R.sup.2 is independently H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl;
• wherein X and Y are CH.sub.2 ;
• wherein n is 0, 1 or 2;
• wherein each p and q is independently 1 or 2;
• wherein R.sup.3 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl;
• wherein R.sup.4 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or COR.sup.3 ;
• and wherein R.sup.5 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl, C.sub.1 -C.sub.6 straight or branched chain alkoxy or OH.

A method for treating benign prostatic hyperplasia in a subject which comprises administering to the subject an amount of a compound having the structure:

• ##STR144## wherein each W, Z.sup.1 and Z.sup.2 is independently H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, OH, F, Cl, Br, I, NO.sub.2, CN, SO.sub.2 NHR.sup.3, NR.sup.4.sub.2, CONR.sup.3.sub.2, COR.sup.5 ;
• wherein each R.sup.1 and R.sup.2 is independently H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl;
• wherein each X and Y is independently CH.sub.2, NR.sup.4, C.dbd.O, S, S.dbd.O, SO.sub.2 ;
• wherein n is 0, 1 or 2;
• wherein each p and q is independently 1 or 2;
• wherein R.sup.3 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl;
• wherein R.sup.4 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or COR.sup.3 ;
• and wherein R.sup.5 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl, C.sub.1 -C.sub.6 straight or branched chain alkoxy or OH.