Pyridinecarboxyimidamide compounds and the use thereof
AssigneeKirin Beer Kabushiki Kaisha
InventorsHideki Okawara, Tatsuo Nakajima, Nobuyuki Ogawa, Tomoko Kashiwabara, Soichiro Kaneta
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AssigneeKirin Beer Kabushiki Kaisha
InventorsHideki Okawara, Tatsuo Nakajima, Nobuyuki Ogawa, Tomoko Kashiwabara, Soichiro Kaneta
Estimating the term…
Disclosed are pyridinecarboximidamides having a vasodilating effect (hypotensive activity or antianginal activity), and acid adduct salts thereof. ##STR1## wherein when R.sup.1 represents an alkyl, hydroxyalkyl, carboxyl, amino, acylamino, alkylamino, dialkylamino, aralkylamino, alkylsulfonamide, bisalkylsulfonylamino or hydroxyl group, R.sup.2 represents a hydrogen atom and R.sup.3 represents a nitroxyl, 2-chlorophenyl or phenyl group; and when R.sup.1 represents a hydrogen atom, R.sup.2 represents an alkyl, hydroxyalkyl, carboxyl, amino, acylamino, alkylamino, dialkylamino, aralkylamino, alkylsulfonamide, bisalkylsulfonylamino or hydroxyl group and R.sup.3 represents a nitroxyl, 2-chlorophenyl or phenyl group. There is also disclosed the use of the compounds represented by the formula (I) for antihypertensive or antianginal purpose.
A pyridinecarboximidamide represented by the formula (I):
A pyridinecarboximidamide represented by the formula (I) ##STR7## wherein R.sup.1 is selected from a hydroxyalkyl, amino, acylamino or alkylamino group, R.sup.2 represents a hydrogen atom, and R.sup.3 represents a nitroxyl, 2-chlorophenyl or phenyl group, or
Dependencies are inferred from the claim text.