Methods of inhibiting thrombin
AssigneeEli Lilly and Company
InventorsDaniel J. Sall, Gerald F. Smith
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Abstract
A method of inhibiting thrombin and its attending diseases and conditions comprising administering to a human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidino, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
Claims4
A method of inhibiting an attending disease or condition where inhibition of thrombin is required, wherein said disease or condition is an atherosclerotic disease, comprising administrating to a human in need an effective amount of a compound of the formula ##STR5## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR6## wherein Ar is optionally substituted phenyl;
- R.sup.2 is selected from the group consisting of pyrrolidino, hexamthyleneimino, and piperidino;
- or a pharmaceutically acceptable salt of solvate thereof.
Dependencies are inferred from the claim text.