5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists
AssigneeMerrell Pharmaceuticals Inc.
InventorsMarcel Hibert, Luc Van Hijfte, Mary Richards, Paul Moser
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Abstract
This invention relates to novel derivatives of 5H-dibenzo (a,d)cycloheptenes, to the processes for their preparation, to their muscarinic receptor antagonist properties and to their end-use application for treating Parkinson's Disease, tardive dyskinesia, and motion sickness.
Claims4
The compound having the following formula or the pharmaceutically acceptable salts thereof ##STR6##
A method for treating Parkinson's disease which comprises administering a therapeutically effective amount of a compound of formula 1 or the pharmaceutically acceptable salts thereof to a subject in need of such therapy, formula 1 being ##STR7## wherein Q is ##STR8## with R being H or CH.sub.3, and X is H, C.sub.1-6 alkyl, halogeno or C.sub.1-6 alkoxy.
A method for treating tardive dyskenesia which comprises administering a therapeutically effective amount of a compound of formula 1 or the pharmaceutically acceptable salts thereof to a subject in need of such therapy, formula 1 being ##STR9## wherein Q is ##STR10## with R being H or CH.sub.3, and X is H, C.sub.1-6 alkyl, halogeno or C.sub.1-6 alkoxy.
Dependencies are inferred from the claim text.