Pyrido[1,2,3-D,E] [1,3,4]benzoxadiazine derivatives

A compound of the formula (I) ##STR160## in which R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl optionally substituted by hydroxyl or halogen,

• R.sup.2 independently of R.sup.1 is hydrogen or methyl,
• R.sup.3 is hydrogen or C.sub.1 -C.sub.4 -alkyl,
• R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl,
• X.sup.1 is hydrogen or halogen and
• Z is a radical of the structure ##STR161## in which R.sup.7 is hydrogen, hydroxyl, --NR.sup.10 R.sup.11, hydroxymethyl, --CH.sub.2 --NR.sup.10 R.sup.11, carboxyl, methoxycarbonyl or ethoxycarbonyl,
• R.sup.10 being hydrogen, C.sub.1 -C.sub.3 -alkyl optionally substituted by hydroxyl, alkoxycarbonyl having 1 to 4 C atoms in the alkoxy moiety, or C.sub.1 -C.sub.3 -acyl, and
• R.sup.11 being hydrogen or methyl,
• R.sup.8 is hydrogen, linear or branched C.sub.1 -C.sub.3 -alkyl or cyclopropyl,
• R.sup.9 is hydrogen or methyl,
• R.sup.6 is hydrogen or methyl,
• R.sup.5 is hydrogen, methyl or a radical of the structure --CH.dbd.CH--CO.sub.2 R.sup.5', --CH.sub.2 --CH.sub.2 --CO.sub.2 R.sup.5', --CH.sub.2 --CO--CH.sub.3 or --CH.sub.2 --CH.sub.2 --CN,
• R.sup.5' being methyl or ethyl, and
• D is --CH.sub.2 --, O or a direct bond,
• it being possible for the compounds of the formula (I) to be present in the form of racemates or as enantiomerically pure compounds, in the form of their pharmaceutically acceptable hydrates and acid addition salts or in the form of their alkali metal, alkaline earth metal, silver and guanidinium salts.