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US 5,508,277 AGranted
Bicyclic pyrimidines
AssigneeAdir et Compagnie
InventorsGilbert Regnier, Alain Dhainaut, Ghanem Atassi, Alain Pierre
Life of this patent
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Abstract
Novel bicyclic pyrimidine compounds for use as drugs and having formula (I). Said novel compounds and physiologically tolerable salts thereof may be used in therapeutics, particularly for suppressing tumour cell resistance to antineoplastic agents. ##STR1##
Claims12
Bicyclic pyrimidine compounds selected from those of formula I:
- ##STR16## wherein:
- T and U, which are the same or different, each represents a --CH-- radical or a nitrogen atom so as to form with the pyrimidinyl group a heterocycle selected from:
- purine, pyrazolo[3,4-d]pyrimidine, and 1,2,3-triazolo[4,5-d]pyrimidine;
- R and R', which are the same or different, each represents an alkyl radical having 1 to 5 carbon atoms inclusive or an alkenyl radical having 2 to 5 carbon atoms inclusive, each in straight or branched chain;
- A represents a heteromonocyclic radical of formula:
- ##STR17## wherein:
- B represents a radical of formula:
- ##STR18## wherein R" is a hydrogen atom or an alkyl radical having 1 to 5 carbon atoms inclusive in straight or branched chain and
- t represents an integer of 1 to 3;
- inclusive
- p is zero or one;
- X and Y, which are the same or different, each represents a hydrogen atom, a halogen atom, or an alkyl or alkoxy radical each having 1 to 5 carbon atoms inclusive in straight or branched chain;
- m and n, which are the same or different, each represents an integer of 1 to 3 inclusive;
- R.sub.1 and R.sub.2, which are the same or different, each represents a hydrogen atom or an alkyl radical having 1 to 5 carbon atoms inclusive in straight or branched chain, or together represent a single bond, an oxygen or sulphur atom, a radical --(CH.sub.2).sub.r -- in which r represents an integer of 1 to 3inclusive, a radical --CH.dbd.CH--, --O--CH.sub.2 --, --S--CH.sub.2 --, --SO.sub.2 --CH.sub.2 --, or --CO-CH.sub.2 --,
- R.sub.3 represents a hydrogen atom or a phenyl radical;
- and the chiral compounds and their enantiomers, and their physiologically tolerable salts with appropriate acids.
13 more elements
Dependencies are inferred from the claim text.