Loading patent…
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsWilliam R. Moyle, Robert K. Campbell, Gordon J. Macdonald, Yi Han, Yanhong Wang
Estimating the term…
The present invention pertains to an alpha, beta-heterodimeric polypeptide having binding affinity to vertebrate luteinizing hormone (LH) receptors and vertebrate follicle stimulating hormone (FSH) receptors comprising a glycoprotein hormone alpha-subunit polypeptide and a non-naturally occurring beta-subunit polypeptide, wherein the beta-subunit polypeptide is a chain of amino acids comprising the following four joined subsequences: (a) a first subsequence homologous to the amino acid sequence of residues 1-93 of the beta-subunit selected from the group consisting of human chorionic gonadotrophin (hCG), vertebrate luteinizing hormone (LH), vertebrate follicle stimulating hormone (FSH), and vertebrate thyroid stimulating hormone (TSH); (b) a second subsequence homo logous to the amino acid sequence of residues 94-97 of the beta-subunit selected from the group consisting of human chorionic gonadotrophin (hCG) and vertebrate luteinizing hormone (LH); (c) a third subsequence homologous to the amino acid sequence of residues 98-100 of the beta-subunit selected from the group consisting of human chorionic gonadotrophin (hCG), vertebrate luteinizing hormone (LH), vertebrate follicle stimulating hormone (FSH), and vertebrate thyroid stimulating hormone (TSH); and (d) a fourth subsequence homologous to the amino acid sequence of residues 101-110 of the beta-subunit of vertebrate follicle stimulating hormone.
An alpha, beta-heterodimeric polypeptide having binding affinity to vertebrate luteinizing hormone (LH) receptors and vertebrate follicle stimulating hormone (FSH) receptors consisting essentially of a glycoprotein hormone alpha-subunit polypeptide and a non-naturally occurring beta-subunit polypeptide, wherein the beta-subunit polypeptide is a chain of amino acids comprising the following four sequentially joined subsequences:
An alpha, beta-heterodimeric polypeptide having greater binding affinity than luteinizing hormone (LH) for vertebrate follicle stimulating hormone (FSH) receptors consisting essentially of a glycoprotein hormone alpha-subunit polypeptide and a non-naturally occurring beta-subunit polypeptide, wherein the beta-subunit polypeptide is a chain of amino acids comprising the following four sequentially joined subsequences:
An alpha, beta-heterodimeric polypeptide having greater binding affinity than luteinizing hormone for follicle stimulating hormone (FSH) receptors consisting essentially of a glycoprotein hormone alpha-subunit polypeptide and a non-naturally occurring beta-subunit polypeptide, wherein the beta-subunit polypeptide is a chimera comprised of amino acids 1-100 of any vertebrate glycoprotein hormone homologous to amino acids found in residues 1-100 of human chorionic gonadotropin and any 1-20 amino acids.
Dependencies are inferred from the claim text.