Process for producing alpha-hydroxy acid or alpha-hydroxyamide by microorganisms
AssigneeNitto Chemical Industry Co., Ltd.
InventorYoshihiro Hashimoto
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AssigneeNitto Chemical Industry Co., Ltd.
InventorYoshihiro Hashimoto
Estimating the term…
A process for the production of .alpha.-hydroxy acids or .alpha.-hydroxyamides in which an .alpha.-hydroxynitrile compound or a mixture consisting of an aldehyde and prussic acid, which corresponds to the nitrile compound, is allowed to undergo a microbial reaction to produce the corresponding .alpha.-hydroxy acid or .alpha.-hydroxyamide, wherein the improvement resides in that phosphite ions or hypophosphite ions are allowed to be present in the reaction system. According to the present invention, since hydrolysis or hydration of nitrile compounds can be carried out by constantly keeping a low concentration level of aldehydes which are considered to be a cause of the enzyme inhibition in the reaction system, the enzyme activity can be maintained stably for a prolonged period of time and the formed acids or amides can therefore be accumulated in a high concentration.
A process for producing .alpha.-hydroxy acids or .alpha.-hydroxyamides by microorganisms, in which an .alpha.-hydroxynitrile compound represented by the following general formula (1) or a mixture consisting of an aldehyde represented by the following general formula (2) and prussic acid is allowed to undergo a microbial reaction to produce the corresponding .alpha.-hydroxy acid or .alpha.-hydroxyamide represented by the following general formula (3), wherein the improvement resides in that phosphite ions or hypophosphite ions are allowed to be present in the reaction system:
Dependencies are inferred from the claim text.