Polyisobutylene adhesives for transdermal devices
AssigneeAlza Corporation
InventorsKarly S. Wang, James L. Osborne, James A. Hunt, Melinda K. Nelson
Life of this patent
Estimating the term…
Abstract
An in-line adhesive, useful for transdermal delivery devices comprising a mixture of high and low molecular weighted polyisobutylene having a ratio HMW PIB:LMW PIB in the range of about 5-40:95-60 which is substantially free of plasticizers and tackifiers is disclosed. The adhesive finds particular use as a component of a transdermal delivery device for delivering oily non-polar agents such as nicotine, benztropine, secoverine, dexsecoverine, and arecoline.
Claims20
A polyisobutylene (PIB) adhesive composition for use in a transdermal active agent delivery device, said adhesive composition comprising an oily, non-polar liquid active agent dissolved in a polymeric component consisting essentially of a mixture of high molecular weight (HMW) PIB having an average molecular weight in the range of about 450,000-about 1,600,000 and low molecular weight (LMW) PIB having an average molecular weight in the range of about 1,000-about 450,000, the ratio HMW PIB:LMW PIB being in the range of 5-40:95-60;
- said adhesive composition being substantially free of plasticizers and tackifiers.
A polyisobutylene adhesive composition for use in a transdermal nicotine delivery device, said adhesive composition comprising nicotine dissolved in a polymeric component consisting essentially of a mixture of HMW PIB having an average molecular weight in the range of about 450,000-about 1,600,000 and LMW PIB having an average molecular weight in the range of about 1,000-about 450,000, the ratio HMW PIB:LMW PIB being in the range of 5-40:95-60;
- said adhesive composition being substantially free of plasticizers and tackifiers.
A transdermal delivery device for delivering an oily, non-polar active agent comprising:
- a) reservoir means containing said active agent;
- b) an in-line adhesive comprising:
- (i) a polymeric component consisting essentially of a mixture of high molecular weight (HMW) PIB having an average molecular weight in the range of about 450,000-about 1,600,000 and low molecular weight (LMW) PIB having an average molecular weight in the range of about 1,000-about 450,000, the ratio HMW PIB:LMW PIB being in the range of 5-40:95-60;
- and
- (ii) said active agent;
- said adhesive being substantially free of plasticizers and tackifiers;
- and
- c) active agent release rate controlling means disposed between said reservoir means and said in-line adhesive.
A transdermal nicotine delivery device comprising:
- a) reservoir means containing nicotine as active agent;
- b) an in-line adhesive comprising:
- (i) a polymeric component consisting essentially of a mixture of HMW PIB having an average molecular weight in the range of about 450,000-about 1,600,000 and LMW PIB having an average molecular weight in the range of about 1,000-about 450,000, the ratio HMW PIB:LMW PIB being in the range of 5-40:95-60;
- and
- (ii) nicotine;
- said adhesive being substantially free of plasticizers and tackifiers;
- and
- c) nicotine release rate-controlling means disposed between said reservoir means and said in-line adhesive.
A device for the transdermal administration of nicotine as an active agent, said device comprising:
- a) a subsaturated nicotine reservoir containing up to about 40 wt % nicotine;
- and
- b) an adhesive disposed in the path of nicotine migration from said nicotine reservoir to the skin, said adhesive comprising nicotine dissolved in a polymeric component consisting essentially of HMW PIB having an average molecular weight in the range of about 450,000-about 1,600,000 and LMW PIB having an average molecular weight in the range of about 1,000-about 450,000, the ratio of HMW PIB:LMW PIB being in the range of about 5-40:95-60, said adhesive being substantially free of plasticizers and tackifiers.
Dependencies are inferred from the claim text.