Topical antiperspirant composition consisting essentially of non-toxic water-insoluble occlusive film-forming antiperspirant polymer

#Topical antiperspirant compositions, in the present case containing no or a reduced quantity of a metal salt such as aluminum or zirconium chlorohydrate, but which essentially rely upon a non-toxic occlusive water-insoluble film-forming polymer for their primary antiperspirant activity and utility.

#Antiperspirants are socially and cosmetically desirable products. Aluminum and zirconium chlorohydrates are Category I antiperspirant actives and products containing the same can be legally designated "antiperspirants". Other metal salts have been found to be effective, but have not found their way to the marketplace for many valid reasons. Anticholinergics, including scopolamine derivatives, are the most effective antiperspirants known. However, because of their poor skin-penetration properties, they require injections for effectiveness. Antiadrenergics have also been investigated, but have only developed academic interest. Aldehydes such as formaldehyde can suppress sweating, but their sensitization potential has eliminated commercialization. Metabolic inhibitors such as ouabain have been studied academically. Accordingly, at present, there is no really viable substitute for aluminum and zirconium chlorohydrates.

#Antiperspirant compositions by definition must reduce or eliminate perspiration, at least in a designated area to which they are topically applied and, due to constant elevation of antiperspirant aims and objectives, are constantly increasing in their effectiveness, which by some standards must reduce perspiration by at least 20% in 50% of the population, although in many cases the attainment of such high percentage is not and may never be possible. Although numerous compositions have been proposed as antiperspirants, few of them have been successfully marketed because of their failure to provide effective antiperspirant relief or due to the production of irritation or other undesirable side effect and, after all these years, the most effective and successful antiperspirant compositions are still those comprising large proportions and amounts of aluminum or zirconium chlorohydrate or like mineral salts which retard the perspiration phenomenon, despite their frequently irritating nature and their undesirability from the standpoint of inherent toxicity.

#The following Examples are given to illustrate the compositions or formulations and the method of the present invention, but are not to be construed as limiting.

#Various formulas have been developed, each exhibiting a significant reduction in perspiration due to the occlusive film produced on the under-arms (i.e., armpits) of the subjects involved in the testing procedure, which among other things has involved a hot room or modified sauna test study, to evaluate the prototypes and improved modifications thereof, with improvements in providing a less tacky film and a more flexible film being among the objectives of the formulation variations. Reductions in under-arm perspiration have ranged from the approximately 12% reduction in perspiration employing liquid formula FT-5-015, through the 17% reduction in perspiration from the occlusive film produced on the under-arms with the employment of dab-on formula FT-4-001, up through the advanced stick formula FT-8-014B, which produced more than a 34% reduction in perspiration. Maximum perspiration reduction was greater than 50%, as will be seen from the following.

#Preparation Procedure: