Processing of fibrous connective tissue
AssigneeOsteotech, Inc.
InventorsAnnamarie B. Prewett, Robert K. O'Leary
Life of this patent
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Abstract
Fibrous connective tissue for surgical implantation is made substantially antigen-free by contact with one or more extraction agents. Solutions or mixtures of molecules having bipolar regions act as antigen removing permeation enhancers. Cationic, anionic, non-ionic or amphoteric surfactants are suitable bipolar permeation enhancers. One or more extraction agents can be combined to form extraction mixtures.
Claims29
A process for removing a material selected from the group consisting of antigens, antigen generating material, tendon cells, ligament cells, cellular debris and inflammatory agents from fibrous tissue comprising contacting the fibrous tissue with at least one extraction agent for a sufficient time to remove said material from the fibrous tissue, wherein the at least one extraction agent includes at least one polyol.
Dependencies are inferred from the claim text.