Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
AssigneeAlcon Laboratories, Inc.
InventorGerard Llanos
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Abstract
Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized end-capped PEO which is attached at one end to the medical device. The PEO compounds are then exposed to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network. These PEO coatings are able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.
Claims6
A PEO-coated implantable medical device which can be sterilized by ethylene oxide sterilization without substantial loss of the PEO coating's protein and/or cell repulsion ability, wherein the device comprises a PEO coating comprising cross-linked, .alpha.,.omega.-aldehyde-terminated PEO compounds having a number average molecular weight from 200-100,000, and wherein at least one of the .alpha.,.omega.-aldehydes of the PEO compounds is attached to the implantable medical device and the cross-linking is achieved by exposure to a high energy source.
Dependencies are inferred from the claim text.