Genistein for use in inhibiting osteroclasts
AssigneeThe UAB Research Foundation
InventorsStephen Barnes, Harry C. Blair
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Abstract
Disclosed are methods and compositions for use in inhibiting osteoclast activity and, particularly, the osteoclast acid secretion that leads to bone-degradation. It is shown that the isoflavone genistein inhibits the acid secretion of osteoclasts and reduces bone resorption. The present invention thus provides advantageous methods for use in inhibiting osteoclast activity, as may be employed to reduce bone loss, for example, in patients with osteoporosis, metastatic bone cancers and renal failure.
Claims27
A method for reducing acid secretion by osteoclasts, comprising contacting an osteoclast with a composition comprising an amount of a genistein-glucoside conjugate that occurs naturally in soy, the amount effective to inhibit osteoclast acid secretion.
A method for reducing bone resorption, comprising administering to an animal exhibiting symptoms associated with bone resorption an amount of a pharmaceutically acceptable composition comprising a genistein-glucoside conjugate that occurs naturally in soy, the amount effective to reduce acid secretion by osteoclasts located within the animal.
A method for treating osteoporosis, comprising administering to a patient suspected of having osteoporosis a pharmacologically effective amount of a pharmaceutically acceptable genistein-glucoside conjugate composition that occurs naturally in soy.
Dependencies are inferred from the claim text.