Systemic administration of a therapeutic preparation
AssigneeAstra AB
InventorsKjell G. E. Backstrom, Carl M. O. Dahlback, Peter Edman, Ann C. B. Johansson
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Abstract
A method of treating a patient in need of insulin treatment, including the steps of introducing into the lower respiratory tract of the patient an effective amount of a therapeutic preparation in the form of a dry powder containing (a) insulin and (b) an enhancer compound which enhances the absorption of insulin in the lungs of the patient.
Claims20
A method of treating a patient in need of insulin treatment, comprising introducing into the lower respiratory tract of said patient an effective amount of a dry powder formulation comprising active compounds (a) insulin and (b) an enhancer which enhances the absorption of insulin in the lower respiratory tract of said patient, said dry powder formulation being suitable for inhalation.
A method of treating a patient in need of insulin treatment, comprising introducing into the lower repiratory tract of the patient a dry powder pharmaceutical preparation comprising active compounds (a) insulin and (b) an enhancer which enhances the systemic absorption of insulin in the lower respiratory tract of said patient, said preparation being in the form of a dry powder in which at least 50% of the total mass of active compounds consists of particles having a diameter of about 10 microns or less, wherein the plasma pharmacokinetics of said insulin delivered by said method more closely resemble the plasma pharmacokinetics of endogenous insulin secreted by a healthy individual in response to a glucose challenge, than do the plasma pharmacokinetics of human insulin delivered by subcutaneous injection.
Dependencies are inferred from the claim text.