Aminobenzosultam derivatives as lipoxygenase inhibitors
AssigneePfizer Inc.
InventorsMasami Nakane, Kunio Satake, Kazuo Ando, Hiroaki Wakabayashi
Life of this patent
Estimating the term…
Abstract
Aminobenzosultam derivatives, which are inhibitors of lipoxygenase, having the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein Ar is cycloalkyl having five to seven carbon atoms, tetrahydropyranyl, pyridyl, oxazolyl, phenyl or substituted phenyl wherein said substituent is methyl, methoxy, fluoro, chloro or trifluoromethyl; n is an integer of 1 to 3; X is hydrogen, methyl, methoxy, fluoro, chloro or trifluoromethyl; Z is --NH--, --O--, or --CH.sub.2 --; and R.sup.1 is hydrogen or alkyl having one to three carbon atoms.
Claims4
A compound of the formula ##STR5## and the pharmaceutically acceptable acid addition salts thereof, wherein Ar is cycloalkyl having five to seven carbon atoms, tetrahydropyranyl, pyridyl, oxazolyl, phenyl or substituted phenyl wherein said substituent is methyl, methoxy, fluoro, chloro or trifluoromethyl;
- n is an integer of 1 to 3;
- X is hydrogen, methyl, methoxy, fluoro, chloro or trifluoromethyl;
- Z is --NH-- or --O--;
- and R.sup.2 is hydrogen or alkyl having one to three carbon atoms.
Dependencies are inferred from the claim text.